Power saving modes generally return to normal with the pressing of enter on the keyboard or clicking of the mouse. This may not happen though if the devices are not plugged directly into a rear USB or PS2 port that is on the motherboard. Hubs, expansion ports (on an expansion card), some types of front ports, and possibly USB3 ports will not be powered or monitored during power saving modes so should not be used for these simple devices.
Otherwise refer back to response #1
You have to be a little bit crazy to keep you from going insane.