Mouse issues after changes to registry

Hi, I lose usage of my mouse when I reboot XP after the following actions: 1. registry clean up with CCleaner OR 2. disabling of one or more unncessary service(s) from within services.msc I also noticed that when I reboot one more time the mouse issue goes away, but it reappears at the next reboot and so on (it appears every two reboots...). Each time I have been able to reverse changes OK by coming back to the System Restore point I had created before the changes. Any idea as to what could be the issue and next troubleshooting steps?

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