Mouse issues after changes to registry

Hi, I lose usage of my mouse when I reboot XP after the following actions: 1. registry clean up with CCleaner OR 2. disabling of one or more unncessary service(s) from within services.msc I also noticed that when I reboot one more time the mouse issue goes away, but it reappears at the next reboot and so on (it appears every two reboots...). Each time I have been able to reverse changes OK by coming back to the System Restore point I had created before the changes. Any idea as to what could be the issue and next troubleshooting steps?

• › [Solved] .exe file extentions have changed to .lnk
• › [Solved] From 1.75GB of RAM to 768MB of RAM
• › [Solved] Batch open & resize windows file explorer windows
• › System Restore Issue In Windows XP
• › [Solved] How to repair icons?
• › why does my usa msn keep switching back to thai page
• › [Solved] How to fix my desktop that will not boot up