computer hangs when trying to open a file.

I have made a photo slide show using photo DVD maker software.But,after saving the slide show when I tried to open the slide show,it is not opening.Moreover, during the process of opening the file, computer completely hangs up.no command including START & Windows Task Manager is working.Computer is not shutting down.Switch off the power is the only way to shutting down the computer.The file is also not deleting.When try to delete,it is giving the message "Can't delete the file,other programme is using it".Please help.

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