|Usb for most common thing are fully supported in Vista. |
Unless there is some applications that came with the drive, then that would be slightly different than a driver as such.
Guess you could look at the OEM site of the drive and see. Bet they would only offer Win98 and below drivers.
"Best Practices", Event viewer, host file, perfmon, antivirus, anti-spyware, Live CD's, backups, are in my top 10