|There is probably a third-party device driver interfering with the mouse driver.|
When you start in Safe Mode, third-party device drivers are not loaded, so that's a clue as to what's causing the problem.
Have you recently installed a new device and/or a driver?
If yes, that is almost certainly what's causing the conflict so you will need to uninstall it, whatever it is.
Remember also that some types of software also install drivers, it doesn't have to be for a device. Examples of this are third-party firewalls, antivirus software, and CD/DVD burning software.