Apart from "No",
I have a couple of questions:
It wouldn't need to make any calculations, just give a true/false result.
How can Excel return a result without performing any calculations. If different cells have varying values, then some form of logic is required.
How do you propose to select the cells in the four columns shown in your image (call them A to D for example)
If you used Validation drop-down lists in four cell, say A1 to D1
and A1 could only be:
A, B, C, D or E
and B1 could only be:
1, 2. 3, 4 or 5
and so on, then:
the result in another cell can be based on the results in cells A1 to D1