|Are you saying that your mouse might move for a bit then just after you move it the mouse freezes?|
Try safe mode at boot to start. Maybe bios for usb if usb mouse. Might be a conflict.
Try a linux live cd and see if mouse works.
"Best Practices", Event viewer, host file, perfmon, antivirus, anti-spyware, Live CD's, backups, are in my top 10