|If you click on a desktop icon to have it reboot to msdos mode and then start the game then when it reboots it swaps different versions of config.sys and autoexec.bat. If those different versions don't have the sound blaster stuff loading then your card won't work. You would need to manually edit the dos versons of those files to add the relevent lines or use the sound blaster installation disk and install them when you're in dos mode.|
If you're rebooting to msdos mode via the shutdown menu there's a file called DOSSTART.BAT in the windows directory that runs. It's basically an autoexec.bat. You need the soundblaster dos stuff that is probably loading in the regular autoexec.bat (c:\autoexec.bat) to load in dosstart.bat. You'll need to manually edit dosstart.bat so it has the same dos soundblaster lines as are in autoexec.bat.
The original config.sys file is still in effect when booting to dos with the shutdown menu so no changes need to be made to it.
It's possible you won't have a dosstart.bat file if it was never set up to run that way.
Post back which method you're using to get to dos mode.