|So you're saying you still have all your content but the drive is nolonger called E:?|
If E: isn't already taken by something else, you can call it E: by going into Control Panel>>Administrative Tools>>Computer Management then under Disk Management, find the drive that is nolonger E:, right click on it then click "Change Drive Letter and Path" then click on "Change" and select E:. If it's not in the list, it's being used by something else.
AMD64 X2 4200 @2.5Ghz
Corsair 3Gig Dual-Channel 2x512 2x1gig
Seagate 160Gig SATA
Seagate 320Gig SATA