|If it doesn't work when booted from the windows install disc, then there is something seriously wrong. |
Inspect all your USB ports, make sure that none of them are broken with the pins all smashed in and shorting out on the ground shielding.
Other then that, does the light on the mouse light up? can you check to see if a usb drive will light up? dose a usb keyboard work?
You could go into your BIOS and see if there is a setting for Legacy USB Devices and turn that on.
Also let me know what the make and model of the computer you are using.