|"how do i come out of safe mode please?"|
How do you not realize that you're in safe mode? Doesn't it say "safe mode" in the 4 corners of the screen? You normally have to press F8 at bootup & select safe mode from the menu to be able to get into it. If your computer has a problem, it *may* automatically boot into safe mode, but there's usually some input required by the user. Regardless, there may not be anything wrong with Skype at all. You just need to boot into normal mode to get it to work properly.
If there's a problem that's forcing your system into safe mode, you need to figure out what it is & fix it, THEN you'll be able to get into normal mode again. We can't help with that unless you give an idea of what's wrong.
Try booting your machine & immediately start tapping the F8 key unless the options menu comes up. Use the arrow key to highlite "start windows normally", then hit the ENTER key.