|With a twisted cable you have:|
motherboard>>B: drive connector>>twist>>A: drive connector
Unless the drives are jumpered incorrectly. The twist allows both drives to be set at the second DS but recognized separately. If you set both drives at the first DS then I think the drive letters are reversed. Most newer 3.5 drives are either hardwired to the second DS or their jumpers aren't accessible.
You only want the drives to have different DS settings if you are using a cable without the twist
Your cable has a total of four connectors but I guess you realize it can only accomodate 2 drives--one before the twist and one after.
Ignore the third and fourth DS settings on the 5.25. I think they're remnants of some ancient way drives were ID'd.
Real men don't use AntiVirus; they just reformat