What do you hope to accomplish by doing this? Just because you can? I think the mechanical mirrored drive will drag the added performance down. For personal use I don't see that striping will add enough performance to warrant the expense.
Whether or not it can be done would depend on the controller used. But even if possible it is doubtful you would see any significant performance gains. Remember that no form of RAID will avoid the need for maintaining backups. RAID (except RAID 0) protects you from drive failure. It provides no protection whatsoever from other causes of data loss.
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