You obviously can't run any CD/DVD-based software on a netbook. You can only install or run games by downloading them from a website. Alternatively, using a PC or laptop which does have a CD drive, you could buy a 1GB or 2GB pen drive, copy the contents of the game CD to the pen drive, then plug the pen drive into your netbook.
However, most netbooks don't have the required hardware to run games so you may be wasting your time even thinking about it.
Road Rash is an extremely old game. It should be playable on a netbook but you'll need a CD drive to install it. And it will most likely have to be run in Win95/98 compatibility mode. You can try copying the contents of the CD to a USB jump drive & see if it will install from there.
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