Unable to Print or have pop ups IE

The words "across North America" tell me that you have some sort of WAN. Is there a domain and a VPN? Where are the printers located? You have to explain your setup in more detail.

Here are some more details: All our offices North America are networked and each location has its own file and print server. The users are able to print from all other application except IE. Users are printing on the local LAN and not across the WAN. Also a newly discovered issues is that when user try to use MS Word as an editor for Outlook it informs them that Word is not installed or is corrupted but you can open Word by it self and work on documents without any issues.

Are you saying that no one can print from IE at all locations? In other words, are all locations having the same problem? Are all locations having the same Word/OE problem too? If so, is Norton running at all the locations? Is there another AV Program or any program, for that matter, that has been recently installed, across the board?

The issue has only appeared on six computers out of 700 in the region. Most of the users are not in the same office either. We do have McAfee running on all the PC's. We have also ruled out any GP issue.

Now you have to determine what the 6 PCs have in common. Was there an update of any sort, Windows or McAfee? Do the 6 users communicate by email? Could they have all clicked on the same attachment? Look at the event viewer logs and/or run Hijack This.

Unfortunately none of the users have anything in common. They do not work on any of the same files or even the same departments and maybe one or two of them might communicate with each other via email but not all six. we also have all Automatic updates disabled for the users. weather it be for Windows or McAfee. Only the system admin can push the updates to the PCs.