|Depends on the program. Might have to return a few files back to xp. autoexec.nt and config.nt.|
Might have to install with compatibility mode. Then also run in compatibility mode.
Dosbox is a common way too, not fully sure it would work with that game. Seems that plenty of crooks offer it online as a virtual pc machine with Win98 included or at least part of win98.
"Best Practices", Event viewer, host file, perfmon, antivirus, anti-spyware, Live CD's, backups, are in my top 10