|compare what is running in safe mode via task manager and what is running in task manager in regular bootup. What is not showing in safe mode but shows in regular is what you want to isolate.|
For example how many processes are running under a regular bootup and how many are running when in safe mode.
Clearly you have a software issue if it works in safe mode and not in regular mode.
I would use a wired mouse only until the problem is solved. This eliminates electrical interferance as a possible issue with the mouse.