|You can (if you really want to) use the USB drive for the paging file (virtual memory), as long as it has a suitably large capacity. |
The main advantage of doing this is that having the paging file on a drive other than the system files will decrease access time to data in virtual memory. Of course, how much benefit you'll see depends on the version of USB (USB1, USB2, or USB3) your machine and USB drive use. Obviously, USB3 would have the faster data transfer speed.
One disadvantage is that a small capacity USB drive (e.g. a 1GB pendrive) will severely limit the ability of the paging file to grow as needed. If you intend to use a small capacity pendrive, it may well be counter-productive, to the point of inhibiting performance.
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