|I'll assume that you have created a shortcut to start cmd.exe|
Right click on the shortcut and select Properties:
In the Start in: dialog box type the path and name of the start directory e.g. C:\mydir\
In the Shortcut key: dialog box hold down Ctrl + Alt + the hotkey you wish to use e.g. Ctrl + Alt + C Click apply and exit from the shortcut. To open cmd.exe you can now use the combination Ctrl + Alt +C
Did you Google for an answer before asking the question?