|Any particular problems you are having?|
Generally worth putting msconfig in the Run box then looking at what is in the Startup tab. Uncheck anything you don't need or could run from a shortcut instead when required.
Wouldn't hurt to defrag.
Run a quick malware check with these two freebies (in the order given):
(blue "Download Now" button on right).
Download and "Save" the file somewhere. Go to the saved file then double click it to run the program. Use the "Scan" button, followed by the "Clean" button.
(use the "download" button rather than the "buy" button).
Install and Run the program but before running the Scan go to "Settings > Detection and Protection" and put a checkmark in "Scan for rootkits". Quarantine anything it finds.
Always pop back and let us know the outcome - thanks