|If the file was there it would be in C:\users\owners\local settings\temp\ and you'd delete it there. But since the error is that the file is missing then it must not be there. You can do a disk cleanup and delete the temp files if you want but that shouldn't change anything.|
Deleting it with regedit wouldn't delete the file; it would delete references to the file but that's what hijackthis should have done.
Try running hijackthis from safe mode. Again, make sure you check the box to delete that entry and then click the 'fix checked' at the bottom of the hijackthis window.
If the error still shows up you may want to repost in the security and virus forum. They might have some better ideas there.