Are you running Norton 2000? It is not compatible with ME.
I use Norton Systemworks 2001 and 2002 on many systems (2000 is not compatible) but it doesn't operate particularly well with ME if you just let it do it's own thing. You need to use it manually rather than let it schedule tasks or it will start interfering with all sorts of other programs and games when they are running. And, don't let System Doctor run constantly...causes many problems and hogs resources. But all that said, if you use Norton WinDoctor, Norton Disk Doctor and Norton Speed Disk in that order they keep a very neat and tidy system going. Norton Cleansweep is good for moving programs to another drive if you have it installed before the programs are installed. Don't let Norton "automatically" clean out your registry etc. because you take your life in your hands if you do. Symantec's anti-virus definitions, information and tools are very good, up to date and work effectively.
I have always found it necessary to completely uninstall prior to a reinstall or a new install of Norton anything. That means using add/remove, then rebooting, then searching the hard drive for any mentions of Norton or Symantec and removing those folders, then searching the registry for same and removing those keys. Only then do I reinstall anything from Norton. And, while using LiveUpdate to bring Systemworks up to date again, I always disable the anti-virus programs in ctrl-alt-del before running Live Update. I have often found it necessary also to download only one update at a time, even to the point of expanding the + sign beside the update listed for a particular application and downloading only one of the sub-updates. It can also be necessary to reboot between each download of the sub-updates and to remember to deactivate anti-virus each time. It takes quite a while but it works and you then get a good install. If, after you download one update, you get a message which says "you chose not to install the 1 update available" ignore it because it is usually wrong.