I am assuming that when you say "serial mouse slot" you mean the ps/2 slot on the tower? (It's the little round one, there are usually 2 of them, one for mouse and one for keyboard.) I would suggest trying to reinstall your usb drivers, it may take longer, but I believe that me has the option for mouse emulation. hold down on your shift key and wait for about 10 secconds, then tab your way over to mouse emulation, that should let you move around and click on stuff atleast till you can get the drivers looked at,
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