Can't Open or Run most EXE files in Windows 7

January 30, 2010 at 04:44:17
Specs: Windows 7

I have a problem where i can't open most .exe-files. I found someone with simular problems that had recived help from here when i was looking for a sulution

It apears to be the same problem that i have and i think the sulution should work for me to, but my problem is that when i try to run exefix.reg i get a message saying that "some of the keys are opend by the system or other processes" (not the exact wording, freely translated from swedish). Is there a way to override this or do i need a whole other sulution?

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January 30, 2010 at 06:16:25

daoh, Go to the link below and download and run the EXE file association fix for Windows 7. Instructions are are the page. I'm assuming that the problem computer is Windows 7.

Note that the link that you posted was for a problem with Windows XP so that the exefix.reg file you're trying to run is for Windows XP not Windows 7


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January 31, 2010 at 01:16:35

Still have the problem that I can't merge the .reg-file because some keys are used by the system. I manage to do a virusscan with and found a trojan, the problem remains thou, not sure i manage to get rid of the trojan compleatly. I gona try scaning again and see if the trojan shows up again.
-Compleated the scan now and it shows no viruses

Tnx for the quick reply :)

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January 31, 2010 at 08:16:32

daoh, Try merging that reg file in SAFE mode.

Start your computer in safe mode

I would also go to the link below and download Malwarebytes' Anti-Malware Free Version, install it, update it then run it. Remove whatever it finds.

Note: Close all open programs prior to installing.

How to use Malwarebytes' Anti-Malware application on a Windows computer


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Related Solutions

February 1, 2010 at 05:52:42

Have you seen



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February 2, 2010 at 00:57:54

I manage to go thru Regedit and look at every line manualy, they are all the same as in the regfile i try to update with and only one of them are locked [HKEY_CLASSES_ROOT\exefile\Shellex\PropertySheetHandlers\ShimLayer Property Page], but the value that is locked there is the same that the regfile from wants to change it to.

When I did a scan with Malwarebytes' Anti-Malware Free it crashes wvery time I try to do a full scan both in safe and ordinary mode, but fast scan works. On the first run i got
Hijack Display Properties - HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurentVersion\Policies\Explorer\NoActiveDesktopChanges

I used the "fix it" button and did another scan and havn't seen it again.
But the problem still remains, is reformat my best option here or do you guys have any more tricks :)

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February 2, 2010 at 03:34:31

I am sorry I also have one .exe file to my knowledge that has stopped working. That is PowerDVD 7.3 from Cyberlink. This is an old version of PowerDVD, but I keep it because it can play both HD DVD and Bluray disks.

This problem has happened recently after installing KB978207, an update to IE8 that released on 26 th of January.

I did not uninstall the update because of the security risk it would bring. Furthermore, I am not 100% sure that this update caused PowerDVD 7.3 to not work.

I write this as it might give you a hint to your problem. Please just think about it and check if you have the update KB978207 and if your problem coincides with it.



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February 6, 2010 at 14:46:47

Hello there,

i have the same problem with daoh, except for my pc will NOT run any exe file (it only run registry booster), nothing else. I tried everything written here and it doesn't work. The microsoft reg file (for exe fixing) didn't run in safe mode(which again was not succesfull by F8, i had to run msconfig from the start menu).

Guys...seriously, any other tips???This is awful

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February 6, 2010 at 20:50:38

Is it possible that when you installed the windows update/patch that your antiVirus/antiMalware program(s) interfered during the update and left you a damaged update? Could you uninstall, turn off all such programs, and re-download the patch?

If no one has any other suggestions, you might have to back up and do a clean install of Windows 7, do all of your updates, and reinstall your programs.

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February 7, 2010 at 05:38:38

The .exe-files I have been able to run is programs that are 64bit, just thought I should add it if others are having the same problem.

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