Lately I have gotten this message when random clients are logging in: Windows cannot log you on because your profile cannot be loaded. Check that you are connected to the network, or that your network is functioning correctly. If this problem persists, contact your network administrator. This can happen to any client and does not happen to only one. The only solution is to reboot the server, but since this is a rather large office, I really don't want to tell them all to log of while I restart the server 5 times a day. Lately I have been removing the profile folder under Documents and Settings and let it be automatically created again when the user is logging in, and after that manually move over the files. This takes a lot of time and many things are forgotten (such as email clients who have more than one email address) This is really getting to me now and I wonder why this is happening and what I can do to solve it. Running User Profile Hive Cleanup Service does not resolve anything.