|I use SpyBot Immunize, SpywareBlaster and IE7, yet still get them at odd times on various websites. Firefox's Adblock never displays them (even without hosts).|
They have dimimished considerably over a time by adding my own lines to SpyBot Hosts whenever I meet one of these ads. I haven't had any on this particular website for yonks.
This is quite a time consuming process and, at times, it is something of a "black art" to find their true source if applied globally. Not something which could be explained fully without wadges of words, but it can be done.
There are stacks of ready-made hosts files around and maybe some are particularly good at dealing with pop-up ad issues.
Here are the lines which include those I've applied to the ads on this website over the years:
Some may now be redundant on here but might still apply to other websites. Note also that I'm from the UK hence the odd one might need changing for the USA. The last one, for example, only applies to the UK.
some other bloke...