Or use a browser with sandbox built in.
That's good to know, but Sandboxie is much more than just a browser feature.
What Chrome offers in this respect, while better than nothing, offers no advantage compared to Sandboxie.
Sandboxie isn't perfect by any means and subject to glitches - though mainly related to Firefox updates causing it to stop opening correctly in the sandbox.
It's a minor problem as you can fire up any other browser and run it in Sandboxie.
I also use it as a tool. Chrome wont help you if you want to open or run a suspect downloaded file within a protected environment.
It can be quite revealing what some downloads contain.
I'm not recommending anyone try this, but try downloading, say, SpywareBlaster from one of the 'sponsored' links at the top of a typical search page.
Many unwary folk do this; It says SpywareBlaster in the link, but it's from a dodgy, third party adware/malware-merchant,
What you get is an initial .exe which ensures that as well as CCleaner, you get a whole bundle of crappy toolbars, browser hijackers etc.
I did this recently on someone's behalf, but ensured I opened up the download in Sandboxie.... I lost count of the crap it tried to install, including the infamous, Conduit toolbar/search engine. Also present were, SaltarSmart, My PC Backup, Minibar BHO, etc, etc.
I still have the screen shots from the attempted installs.
Fair enough, some, though not all, had untick options, during the process, but we all know folk who blindly just click-click.