ok i have this problem on my girlfriends laptop, if i try to open regedit or msconfig they close right away. also if i use IE/Firefox to search for "registry" etc they close.
i have download Hijackthis, but this also closes, also tried to rename it, but it still closes it. any help will be great.

Have you tried from safe mode?

ive tried running ad aware and spybot and registry mechanic from safe mode, should i run Hijackthis in safe mode and then post here what it says?

this is the log file i got after running it in safemode

Logfile of HijackThis v1.99.1
Scan saved at 10:29:51 AM, on 19/04/2007
Platform: Windows XP SP2 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\ZCfgSvc.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\bad thing scan\bad thing scan.exe

R1 - HKCU\Software\Microsoft\Internet Connection Wizard,ShellNext = http://windowsupdate.microsoft.com/
F3 - REG:win.ini: load=C:\WINDOWS\system32\jpckzbhs\winlogon.exe
F3 - REG:win.ini: run=C:\WINDOWS\system32\jpckzbhs\winlogon.exe
O1 - Hosts: 1.1.1.1 free.grisoft.com
O1 - Hosts: 1.1.1.1 housecall.trendmicro.com
O1 - Hosts: 1.1.1.1 usa.kaspersky.com
O1 - Hosts: 1.1.1.1 ewido.net
O1 - Hosts: 1.1.1.1 www.ewido.net
O1 - Hosts: 1.1.1.1 zonelabs.com
O1 - Hosts: 1.1.1.1 www.zonelabs.com
O1 - Hosts: 1.1.1.1 bitdefender.com
O1 - Hosts: 1.1.1.1 www.bitdefender.com
O1 - Hosts: 1.1.1.1 download.bitdefender.com
O1 - Hosts: 1.1.1.1 upgrade.bitdefender.com
O1 - Hosts: 1.1.1.1 spywareinfo.com
O1 - Hosts: 1.1.1.1 www.spywareinfo.com
O1 - Hosts: 1.1.1.1 merijn.org
O1 - Hosts: 1.1.1.1 www.merijn.org
O1 - Hosts: 1.1.1.1 sysinternals.com
O1 - Hosts: 1.1.1.1 www.sysinternals.com
O1 - Hosts: 1.1.1.1 onguardonline.gov
O1 - Hosts: 1.1.1.1 www.onguardonline.gov
O1 - Hosts: 1.1.1.1 avast.com
O1 - Hosts: 1.1.1.1 www.avast.com
O1 - Hosts: 1.1.1.1 safety.live.com
O1 - Hosts: 1.1.1.1 www.paretologic.com
O1 - Hosts: 1.1.1.1 paretologic.com
O1 - Hosts: 1.1.1.1 services.google.com
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: Norton Internet Security - {9ECB9560-04F9-4bbc-943D-298DDF1699E1} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O2 - BHO: NAV Helper - {BDF3E430-B101-42AD-A544-FADC6B084872} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: Norton Internet Security - {0B53EAC3-8D69-4b9e-9B19-A37C9A5676A7} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O3 - Toolbar: Norton AntiVirus - {42CDD1BF-3FFB-4238-8AD1-7859DF00B1D6} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: Easy-WebPrint - {327C2873-E90D-4c37-AA9D-10AC9BABA46C} - C:\Program Files\Canon\Easy-WebPrint\Toolband.dll
O4 - HKLM\..\Run: [SunJavaUpdateSched] C:\Program Files\Java\j2re1.4.2_03\bin\jusched.exe
O4 - HKLM\..\Run: [Dell QuickSet] C:\Program Files\Dell\QuickSet\Quickset.exe
O4 - HKLM\..\Run: [ATIPTA] C:\Program Files\ATI Technologies\ATI Control Panel\atiptaxx.exe
O4 - HKLM\..\Run: [PRONoMgr.exe] c:\Program Files\Intel\PROSetWireless\NCS\PROSet\PRONoMgr.exe
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [Symantec NetDriver Monitor] C:\PROGRA~1\SYMNET~1\SNDMon.exe /Consumer
O4 - HKLM\..\Run: [RoxioEngineUtility] "C:\Program Files\Common Files\Roxio Shared\System\EngUtil.exe"
O4 - HKLM\..\Run: [RoxioDragToDisc] "C:\Program Files\Roxio\Easy CD Creator 6\DragToDisc\DrgToDsc.exe"
O4 - HKLM\..\Run: [Easy-PrintToolBox] C:\Program Files\Canon\Easy-PrintToolBox\BJPSMAIN.EXE /logon
O4 - HKLM\..\Run: [Logitech Hardware Abstraction Layer] KHALMNPR.EXE
O4 - HKLM\..\Run: [KernelFaultCheck] %systemroot%\system32\dumprep 0 -k
O4 - HKCU\..\Run: [MsnMsgr] "C:\Program Files\MSN Messenger\MsnMsgr.Exe" /background
O4 - HKCU\..\Run: [InternodeUsage] C:\PROGRA~1\INTERN~2\mum.exe
O4 - HKCU\..\Run: [Skype] "C:\Program Files\Skype\Phone\Skype.exe" /nosplash /minimized
O4 - Startup: Adobe Gamma.lnk = C:\Program Files\Common Files\Adobe\Calibration\Adobe Gamma Loader.exe
O4 - Startup: winlogon.lnk = ?
O4 - Global Startup: Adobe Reader Speed Launch.lnk = C:\Program Files\Adobe\Acrobat 7.0\Reader\reader_sl.exe
O4 - Global Startup: Logitech SetPoint.lnk = ?
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\OFFICE11\EXCEL.EXE/3000
O8 - Extra context menu item: Easy-WebPrint Add To Print List - res://C:\Program Files\Canon\Easy-WebPrint\Resource.dll/RC_AddToList.html
O8 - Extra context menu item: Easy-WebPrint High Speed Print - res://C:\Program Files\Canon\Easy-WebPrint\Resource.dll/RC_HSPrint.html
O8 - Extra context menu item: Easy-WebPrint Preview - res://C:\Program Files\Canon\Easy-WebPrint\Resource.dll/RC_Preview.html
O8 - Extra context menu item: Easy-WebPrint Print - res://C:\Program Files\Canon\Easy-WebPrint\Resource.dll/RC_Print.html
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\j2re1.4.2_03\bin\npjpi142_03.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\j2re1.4.2_03\bin\npjpi142_03.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\OFFICE11\REFIEBAR.DLL
O12 - Plugin for .spop: C:\Program Files\Internet Explorer\Plugins\NPDocBox.dll
O16 - DPF: {17492023-C23A-453E-A040-C7C580BBF700} (Windows Genuine Advantage Validation Tool) - http://go.microsoft.com/fwlink/?lin...
O16 - DPF: {8E6AA867-94D4-4B4F-8791-1B048F8C122A} (WebInterface Class) - https://fastsend.com/products/Fsplugin.cab
O18 - Protocol: livecall - {828030A1-22C1-4009-854F-8E305202313F} - C:\PROGRA~1\MSNMES~1\MSGRAP~1.DLL
O18 - Protocol: msnim - {828030A1-22C1-4009-854F-8E305202313F} - C:\PROGRA~1\MSNMES~1\MSGRAP~1.DLL
O18 - Protocol: skype4com - {FFC8B962-9B40-4DFF-9458-1830C7DD7F5D} - C:\PROGRA~1\COMMON~1\Skype\SKYPE4~1.DLL
O20 - Winlogon Notify: Sebring - c:\WINDOWS\system32\LgNotify.dll
O23 - Service: Adobe LM Service - Adobe Systems - C:\Program Files\Common Files\Adobe Systems Shared\Service\Adobelmsvc.exe
O23 - Service: Ati HotKey Poller - Unknown owner - C:\WINDOWS\system32\Ati2evxx.exe
O23 - Service: Automatic LiveUpdate Scheduler - Symantec Corporation - C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Network Proxy (ccProxy) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccProxy.exe
O23 - Service: Symantec Password Validation (ccPwdSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccPwdSvc.exe
O23 - Service: Symantec Settings Manager (ccSetMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccSetMgr.exe
O23 - Service: ISSvc (ISSVC) - Symantec Corporation - C:\Program Files\Norton Internet Security\ISSVC.exe
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: Norton AntiVirus Auto-Protect Service (navapsvc) - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\navapsvc.exe
O23 - Service: RegSrvc - Intel Corporation - C:\WINDOWS\system32\RegSrvc.exe
O23 - Service: Spectrum24 Event Monitor (S24EventMonitor) - Intel Corporation - C:\WINDOWS\system32\S24EvMon.exe
O23 - Service: SAVScan - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\SAVScan.exe
O23 - Service: ScriptBlocking Service (SBService) - Symantec Corporation - C:\PROGRA~1\COMMON~1\SYMANT~1\SCRIPT~1\SBServ.exe
O23 - Service: Symantec Network Drivers Service (SNDSrvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
O23 - Service: Symantec SPBBCSvc (SPBBCSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SPBBC\SPBBCSvc.exe
O23 - Service: Symantec Core LC - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\CCPD-LC\symlcsvc.exe