|Go to Start, navigate to Control Panel, select Uninstall a program/Programs and Features, find S.m2pub.com related programs, and click on Uninstall.|
Clear your hosts file http://support.microsoft.com/kb/972034
Under internet options, change your homepage back to your homepage(instead of m2pub.com. In the same popup click on advanced tab, then the reset at the bottom.(make sure that delete personal settings is clicked) Then close out and reopen.(if you have another browser let me know, I will pass information on clearing that as well.)
note that running the scans is still a great option, however these will eliminate the pop ups while you are doing so.