Disable system restore, reboot, enable system restore and reboot. Here's how:
http://service1.symantec.com/SUPPORT/tsgeninfo.nsf/docid/2001111912274039?OpenDocument&src=sec_doc_nam
Once you have re-enabled system restore create a new restore point:
To create a restore point:
Click Start > All Programs > Accessories > System Tools > System Restore.
In the System Restore wizard, select the box next the text labeled "Create a restore point" and click the Next button.
Type a description for your new restore point. Something like "Before I installed some program that may cause my system major grief" would do just fine, but you don't have to be that descriptive.
Click Create.