I cannot delete or remove the infected file.. avast always report virus on my c:\doc\msdirectxsys.. even if i remove it in regedit on safe mode,, plus can be detect by avast under safe mode xp.. help pls also do email me ur replies. Thanks not so good not so great just better..

Download and update the NOD32 antivirus from their website. Reboot and scan in Safe mode. The new version 2.5 is now available for download.

I actually found the SAME virus on my XP Pro system, same pop-up (C:\Msdirect.sys - Hacktool Rootkit), but foudn it spawning from a file in C:\Windows\System32 called 'setup32.exe'. Try and delete that file. That fixed the problem for me. It is likely that the file that spawns the msdirectx.sys file changes, so a good way to find out what file is the culprit is by going into the Control Panel's logs and check for system events and errors. find out the date whe the msdirectx.sys errors started popping up, then look for files created on that same day in the system32 folder.