Just recently, I went onto a website to find some codes for the new Grand Theft Auto game. I must of hit a bad site, cause right when I went into it, I got some random advertisement pop-ups and they won't stop! I have the updated versions of Ad-Aware, Spybot-Search & Destroy, CWShredder, SpySubtract, and hijackthis (could use some help with hijackthis). I've been running them all the time and they keep finding infections. They'll get rid of them, but they'll keep coming back as well as all the pop-ups. Examples of these pop-ups are system warnings about my PC having spyware, free screensavers, search results for poker online, and a lot more. My computer has been fine until I went onto that one website and starting getting those pop-ups. I'm running 12 Ghosts pop-up blocker and they won't stop them. ANY SUUGGESTIONS!!! PLEASE HELP!!! I feel like I've done everything!!!

I had a similar problem awhile back. Turned out to be a trojan. I would get rid of the spyware but it would just be reinstalled by the trojan later. If I remember correctly I had to find the offending exe file in my windows folder and manually delete it. i think I found it by using msconfig to see what was being run at startup. Sorry i cant be more precise it was awhile ago. And my problem also stemmed from a visit to a nasty website. If you fix it or if you dont try switching your browser to firefox (http://www.mozilla.org/). I find much less of a malware trail since I started using it. Good luck,
Jim

There are a few things you can try. Like dragonbate said, it could possibly be a trojan throwing all that trash up. The first thing to do it is look at your running programs list (ctrl-alt-delete). See if there is anything there that you don't recognize or shouldn't be there. If so, kill them (or try to - alot of times they'll just "respawn" at the top of the list). Turn off System restore (right click on My Computer, select properties and his the System Restore Tab). Reboot your system into safe mode (either by pressing F8 at startup or by going to Start > Run > type in "msconfig" and then hit the Boot.INI tab, tick the /safeboot box and then restart.) When you're in safe mode, run AVG (AVG Antivirus - http://www.grisoft.com)and see what it picks up. If you see the .exe that's the culprit, you can either manually navigate to where it it and delete it or you can let AVG take care of it. While you're in safe mode, it might be a good idea to run through all of your spyware programs as well (update them before you boot into safe mode as you may not have connectivity in safe mode). You can try to reboot now (make sure you go back and turn normal boot on) and see what happens. If that doesn't work, run HiJackThis! and post the log (I think there is a special place to post on here) and I'm sure someone will give you a heads up on what needs to be removed. dragonbate gave a good tip, if you want to browse much more safely, try FireFox from Mozilla, it's much safer (and much more stable by my experience). Post back when you can and good luck Jesse.

I've been having the exact same problem as Jesse, its those darn pop-ups and programs that keep returning even after I disable them in msconfig. They've been driving me nuts.

Thanks for posting those solutions guys, i'm going to try them out as well.

Not much of a technical adviser here but what stopped all popups entirely for me is Stopzilla. Go to http://www.STOPzilla.com to check it out. At the same time I installed the Google bar which comes with a popup blocker. My bar says it blocked 21 popups since I installed it; Stopzilla doesn't tell me a #, but if Google stopped 21, then Stopzilla must have stopped hundreds of thousands by now. Good luck.