I suggest that you uninstall one of your antiviruses because they may conflict.
Download killbox from this link Killbox We will use it later in safe mode.
Please download ATF-Cleaner from this link
http://www.atribune.org/content/view/19/2/ by Atribune. We will use it later in safe mode
Download Ewido Security Suite then set it up this way Ewido Setup Instructions We will run this from safe mode also
We are going to need to run HT in safe mode , if the R1's don't show up after you reboot into normal mode remove them.
Reboot the computer into safe mode by following the directions at this link if needed How to Boot Into Safe Mode
Run HT again in safe mode, close all windows except HT, place a check to the left of the following items and press "fix checked":
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://uk.red.clientapps.yahoo.com/customize/btyahoo/defaults/sp/*http://uk.search.yahoo.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://uk.red.clientapps.yahoo.com/customize/btyahoo/defaults/su/*http://uk.search.yahoo.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Bar = http://uk.red.clientapps.yahoo.com/customize/btyahoo/defaults/sb/*http://uk.docs.yahoo.com/info/bt_side.html
O2 - BHO: (no name) - {C8F21DFE-B35C-4274-82EC-1E072D09025E} - C:\WINDOWS\system32\winbrume.dll
O3 - Toolbar: (no name) - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - (no file)
O3 - Toolbar: (no name) - {0B53EAC3-8D69-4b9e-9B19-A37C9A5676A7} - (no file)
O3 - Toolbar: (no name) - {42CDD1BF-3FFB-4238-8AD1-7859DF00B1D6} - (no file)
All the 016"S they will reload when you need them
Run Killbox from safe mode.Double-click on Killbox.exe to run it.
Put a tick by Standard File Kill.
In the "Full Path of File to Delete" box, copy and paste each of the following lines one at a time.
C:\WINDOWS\system32\winbrume.dll
Click on the button that has the red circle with the X in the middle after you enter each file.
It will ask for confimation to delete the file.
Click Yes.
Continue with that procedure until you have pasted all of these in the "Paste Full Path of File to Delete" box.
Run ATF-Cleaner from safe mode.Double-click ATF-Cleaner.exe to run the program.
Under Main choose: Select All
Click the Empty Selected button.
Run Ewido from safe mode.When the scan has completed, Ewido will create a report.txt file. Click the "Save Report" button on the bottom of the screen and save the log to your desktop.
Please reboot into normal mode and post the ewido log and a new HT log.