|Lesley, you will need more than 1 cleaner.|
Both Regseeker & REG SCRUB XP are super good & individual entries can be selected & backed up.
Once you are sure they are not needed again ( about one week ) they can be deleted.
Do not be supprised if hundreds or thousands of files are found.
My personal use, is to, delete only the Green entries.
Click on Select All and choose > Select all Green items.
Right click on a Green item to delete all Green files.