With VBScript? No, not unless you had an ActiveX object that would do so for you.
You have to realize, VBScript by itself is a very weak scripting language. About the most you could do is get some input from the user via InputBox(), do some computations on it, and spit out the result in a MsgBox. (CScript.exe and WScript.exe do add some additional functionality, however.)
Its power lies in evoking ActiveX. File I/O is handled though ActiveX; registry manipulation is done though ActiveX; Active Directory automation is done thanks to ActiveX; WMI interaction relies on ActiveX. Only my most basic scripts don't include a CreateObject() or a GetObject().
With all that said, if you know Visual Basic for Applications, you pretty much know VBS. (The differences can be found here and here.) Look at some of the VBScript posts in this forum; aside from this site's murdering of white space and my abuses of syntax, you should have no trouble understanding what they do.