|Which two pins are these that are being activated - RTS, CTS, DSR, DTR, Data In, Data Out|
AS it is a serial port all data goes through two pins, Data In and Data Out. All the other pins are control signals that are either activated or deactivated depending on whether the comm port is transmitting, receiving or is idle.
What is it you have connected to the serial port. That can have a bearing on how the port behaves.