I have a win32 application using Attunity to write to a RDB7 database on my Alpha's. I want to fire a DCL command procedure from the VB app to query the RDB table, pull out the data, and run a legacy transaction. I can use Apache to launch a *.com file but, I believe, I must bring up an instance of IE.

Any ideas would be greatly appreciated.

If you use Apache, it is not really VMS, but general CGI programming. You don't have to bring up IE, but set up an IP connection to port 80 (or whatever port the webserver listens on), submit a request and wait for the response. There must be dozens of examples on the internet for this.
But I understand that Attunity has default ODBC and ADO interfaces, which looks to me like a much better solution when you want to query the database.