|What specific data in the profile are you concerned about losing?|
Corrupt profiles can be common in large scale Roaming Profile deployments. It is best not to depend on the profiles to contain important data such as My Documents.
You could use Folder Redirection, again within Active Directory Group Policies to redirect profile data such as Favourites and My Documents, etc.
User data (My Documents) is the most important data your users could lose. If you don't already I would setup a shared folder somewhere on your file server i.e. \\servername\userhome$.
Then within each of your user accounts in Active Directory, configure them to map the home area to a drive letter of your choice using whichever folder share you have just made. I.e. \\servername\userhome$\%username% (the %username% will automatically create a folder within that share named with the username i.e. jbrown).
Then use Folder Redirection to tell My Documents to point to the home area drive letter you have chosen i.e. N:\
Then when the users logon they will have a new drive in My Computer (N:\ or whatever) and their My Documents will be pointing to that location. That folder will be permenantly located on the server but users will be able to access files as if they were stored on their PCs (as long as the server is online).
Does that make sense?
Other than that I don't understand what other data you could be concerned about losing.
IT Services Manager