|Open up the case and make sure the drive's data cable is in good condition and tightly connected.|
If that's not it you may be able to access the drive with a boot cd--maybe one of those 'ultimate' boot cds. Or you can try an NTFS4DOS floppy bootdisk.
Or you can connect it to another computer, either as an internal slave or in an external case.
It's unlikely you can fix it by doing any of that but you may be able to delete or transfer some of your files.
Now that's what I call a sticky situation