|Hubs are fine for low power devices like Mice & keyboards. |
I would just state that there is a reason why makers keep throwing more and more USB ports on their motherboards. Hubs don't work very well unless they are powered ones. Hubs can also step the USB through put to 1.1 speeds. Your best ports to use are those directly attached to the motherboard.
The port 49 you refer to has nothing to do with the USB but rather your network/internet. See the link below.