|Unusual question, so it's a bit of a guess:|
If you have a mechanical HD I would have thought continuously shaking it might shorten its life.
Edge connectors can give trouble due to vibration if oxide has built up over the years. A very slight shift to an area with oxide on it can cause the RAM to play up. This is not physical damage though and can be cured, for a while at least, by cleaning the edge connectors with a soft pencil eraser. Same applies to any add-on cards (graphics, audio etc).
Keep watching for other thoughts.
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