Do you have the pendrive plugged into a USB port directly connected to the mboard, as in one built into the mboard edge, or one directly connected to a USB header on the mboard (e.g. one of two and only two front USB ports on the case, or 2 or 4 ports on a plate in a slot that connect directly to a mboard header)?
If you DO have the pendrive plugged into a port directly connected to the mboard, are you sure you installed it properly? e.g. many devices must have their software installed BEFORE they are plugged in, in order for them to be detected properly and work properly.
If you don't, USB hubs that have more than one port connected to only one directly connected USB port do not work with all devices, even if it is a "powered" hub that has it's own additional power supply.
If you have it plugged into an external USB hub that plugs into only one USB port directly connected to the mboard, or into a port in a hub that might be built into the front of the computer that connects to only one USB port directly connected to the mboard, your pendrive may not work properly or be detected properly.
Other things likely to not work in such a hub - printers, multifunction printer/scanner/etc. devices, scanners, some cameras, etc.
Each USB port directly connected to the mboard is rated to supply a max 500ma (1/2 amp) of current. Most USB connected devices don't draw anywhere near that max current, but some draw a lot more than others. A hub that has multiple ports that share only one directly connected to the mboard USB port share that 500ma capacity if it is an "unpowered" hub (all such hubs built into the computer case or a USB hub card, rather than a USB controller card, in a slot are "unpowered"), or if it is an external "powered" hub, it has an external power supply that connects to the hub so that 500ma can be supplied to every port in the hub if required (you may be able to use the hub with or without plugging it in), but even then, some devices will not work properly or will not be detected properly, and you must plug them into a port directly connected to the mboard.