|"Cooler Master 460w will fit but will it work with my motherboard?"|
Yes, if your present power supply is standard sized. The main connector is two pieces and can be used with 20 or 24 "pin" sockets on the mboard.
"....is the Nvidia 6600 gt any better than the x1300?"
I don't know much about NVidia video chipsets but I believe the X1300 is better.
The NVidia 8xxx or 9xxx series would probably be better than the X1300.
I could suggest an ATI (Radeon) video chipset card, but in any case, what are you willing to spend?
"Can I use a PCI Express card with the motherboard?"
NO, not with your mboard.
AGP or PCI (without the -E or Express)
An AGP video card performs better than a PCI (without the -E or Express) card.
click on Knowledge base
Product Category - Desktops
Product Model - MD1467
(the list is not strictly in numerical order)
Search for: specifications
Search for: all
User's manual (for your Medion model; may be generic, for your computer case).
Customer Care - Download library
Enter the serial number of your system -
see "Where can I find my identification number?"
According to the specs...
"Mainboard - MSI MD-5000 (MS 6701)"
NOTE that the mboard may have a MSI bios version (same as for the MSI retail model) or a Medion bios version (brand name specific) .
If it has a Medion bios version, do not use MSI bios updates, because you can't be sure they will work, and if they don't your mboard may never boot again after flashing the bios.
To find ram that will work in your mboard for sure, you use the Medion model (MD1467) if Medion is listed, or the mboard model (MSI or Microstar MD5000 or MS-6701) to search for ram listed for your computer, on a web site where you can look up the ram for your model.
MSI - MD5000 (MS-6701) on the Kingston web site
(No Medion listings.)
Microstar - MS-6701 on the Crucial web site:
(Crucial lists some Medion models but not yours.)
If it's brand name ram, once you know which module ID strings (part numbers) work in your mboard, you can get them from anywhere you like that has ram with those ID strings (part numbers).
Medion - MD1467 on the Memory Giant site:
(MSI - no listing for MD5000 or MS-6701)
Memory Giant doesn't specify the brand - it may be generic ram - but it's guaranteed to work in your mboard.