|Your floppy drive isn't an optical drive so we don't care about that.|
So your D: drive is also an optical drive and the cd's work in that one? If so, perhaps there's a WMP setting that has it only looking for media disks in D:
You may want to open the case and make sure the data cable going to E: is tightly connected and in good condition.
If that's not it try disconnecting D: so that E: is the only optical dirve and see if that helps.
Real men don't use AntiVirus; they just reformat