|USB devices may not work correctly when they're connected to certain USB ports e.g. ports in a hub or on the front of a desktop case. If you have a desktop computer, you may have an IRQ sharing problem you need to fix. |
See response 3 in this:
Included at the end of that is how to properly unload and re-load your USB stack - it's usually not necessary to do that for a laptop.
Also - if you are using a USB extension cable, some of them have inadequate wiring and will not work properly with some USB devices.
If none of those things is your problem, rarely, certain USB devices will conflict with each other, and you may or may not get any indication of that in Windows - System Information on the left side. Try plugging in one USB device at a time until you determine which two specific devices have a conflict problem.
If any of your mice are "combo" ones that can be connected via a USB or PS/2 connection, connecting it via the PS/2 connection may make the problem go away.
(It must be a "combo" mouse that is wired up and designed to be used with either of both types of connection - a simple gender adapter will not work otherwise).