|You need to supply more details on what and why you are doing. Is the computer a brand name pre-assembled computer that you have started with?|
What was the reason for the motherboard replacement?
Are you using any adapters on the hard drive?
When are you seeing the Disk read error?
You may need to re-install Windows 7 or at least perform a repair. You may also need to supply hardware drivers for components on the new motherboard.
Do you have the hard drive set as the first hard drive to boot to?