|Try to make a folder called autorun.inf on it. If it fails then it could be that somehow a file (might be hidden) is on it that is running or trying to run something. It may be a virus.|
If you can make an autorun.inf named folder then still basically some program is trying to access data on the drive. May have to scan registry for some clue to the drive letter. May have to get sysinternal apps to diag more.
"The era of big government is over," said Clinton 1996