|Booting to large hard drives require you to initialize the hard drive to GPT rather than the default MBR for Windows 7. This can get a little tricky and I do not know if the Chipset/BIOS of your era motherboard supports this. There is a lot of detail here on it:|
I personally would recommend using your large hard drive for storage and getting an SSD (120GB to 240GB) or a smaller 500GB HD for your boot drive. This is much simpler, easier on the back up and repair, and in the case of an SSD, much better performance. Your board and Windows 7 do easily support a GPT drive as a storage drive with an MBR bootable drive.
You have to be a little bit crazy to keep you from going insane.