|"Keyboard & Mouse works under Bios & in Windows repair mode."|
A mouse often does not work in the bios in any case.
In that case, if they're both USB connected, there is nothing wrong with the USB ports they're plugged into, the USB controllers are enabled in the mboard's bios, and Legacy USB devices or similar are enabled in the bios.
Windows 98 and up recognizes the USB 1.x features of USB controllers automatically. USB 2.0 and 3.0 controllers are backwareds compatible with USB 1.x specs, so all USB ports should work even when the USB 2.0 or 3.0 controller drivers are not loaded in Windows.
If this is a desktop computer, you may have an IRQ sharing problem in Windows that you need to fix regarding one or more of the IRQs the USB controllers are using. That's the only thing I can think of that could cause both a USB keyboard and a USB mouse to not work in Windows at the same time, when they work otherwise.