|Short answer is yes. First, here's your motherboard manual.|
Description of motherboard connectors starts on page 47 (2-25) of the manual. The oops! page is page 49 (2-27); you can run a total of 6 drives (hdd and optical) under W2K or XP but only 4 drives under Win9x or DOS. Note the "required IDE configuration setting in BIOS" chart.
Since no mention is made of Linux, worst case scenario is that you have a maximum of 4 drives available. Examples would be 2 hdd's and 2 optical drives or 3 hdd's and 1 optical drive, etc.
What you need to make clear to us now is the manufacturer and model numbers of the drives you'd like to use; all of 'em, as in both hdd and optical drives.
Are you able to install Windows 2000 or XP on this machine? It might be necessary if you want to be able to configure for 6 total drives.
Pics would be fine. We need to know how it's all configured now.